Fibroepithelial tumors

Juvenile fibroadenoma

Juvenile papillomatosis

Gliomas, glioneuronal tumors, and neuronal tumors

Pediatric-type diffuse low-grade gliomas

Diffuse astrocytoma, MYB or MYBL!-altered

Angiocentric glioma

Polymorphous low-grade neuroepithelial tumor of the young

Diffuse low-grade glioma, MAPK pathway-altered

Pediatric-type diffuse high-grade gliomas

Diffuse midline glioma, H3 K27-altered

Diffuse hemispheric glioma, H3 G34-mutant

Diffuse pediatric-type high grade glioma, H3-wildtype and IDH-wildtype

Infant-type hemispheric glioma

Circumscribed astrocytic gliomas

Pilocytic astrocytoma

High-grade astrocytoma with piloid features

Pleomorphic xanthoastrocytoma

Subependymal giant cell astrocytoma

Astroblastoma, MN1-altered

Glioneuronal and neuronal tumors

Ganglioglioma

Desmoplastic infantile ganglioglioma/desmoplastic infantile astrocytoma

Dysembryoplastic neuroepithelial tumor

Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters

Diffuse leptomeningeal glioneuronal tumor

Multinodular and vacuolating neuronal tumor

Ependymal tumors

Supratentorial ependymoma

Supratentorial ependymoma, ZFTA fusion-positive

Supratentorial ependymoma, YAP1 fusion-positive

Posterior fossa ependymoma

Posterior fossa group A (PFA) ependymoma

Posterior fossa group B (PFB) ependymoma

Spinal ependymoma

Spinal ependymoma, MYCN-amplified

Myxopapillary ependymoma

Choroid plexus tumors

Choroid plexus papilloma

Atypical choroid plexus papilloma

Choroid plexus carcinoma

CNS embryonal tumors

Medulloblastomas, molecularly defined

Medulloblastoma, WNT-activated

Medulloblastoma, SHH-activated and TP53-wildtype

Medulloblastoma, SHH-activated and TP-53 mutant

Medulloblastoma, non-WNT/non-SHH

Medulloblastomas, histologically defined

Medulloblastoma, histologically defined

Other CNS embryonal tumors

Atypical teratoid/rhabdoid tumor

Cribriform neuroepithelial tumor

Embryonal tumor with multilayered rosettes

CNS neuroblastoma, FOXR2-activated

CNS tumor with BCOR internal tandem duplication

CNS embryonal tumor NEC/NOS

Pineal tumors

Pineal tumors

Pineoblastoma

Melanocytic CNS tumors

Diffuse meningeal melanocytic neoplasms: melanocytosis and melanomatosis

Tumors of the sellar region

Pituitary endocrine tumors

Pituitary adenoma/Pituitary neuroendocrine tumor

Pituitary blastoma

Craniopharyngiomas

Adamantinomatous craniopharyngioma

Liver tumors

Epithelial tumors

Hepatoblastoma

Fibrolamellar variant of hepatocellular carcinoma

Pediatric hepatocellular carcinoma

Mesenchyal tumors unique to the liver

Mesenchymal hamartoma

Calcifying nested stromal-epithelial tumor

Embryonal sarcoma of the liver

Hepatic congenital hemangioma

Hepatic infantile hemangioma

Hepatic angiosarcoma

Pancreatic tumors

Epithelial tumors

Pancreatoblastoma

Pancreatic acinar cell carcinoma

Solid pseudopapillary neoplasm

Gastrointestinal tumors

Epithelial tumors

Gastroblastoma

Appendiceal neuroendocrine tumors

Thyroid tumors

Thyroid epithelial tumors

Follicular adenoma of the thyroid

Papillary thyroid carcinoma

Cribriform morular thyroid carcinoma

Medullary thyroid carcinoma

Spindle epithelial tumor with thymus-like elements

Parathyroid tumors

Parathyroid endocrine tumors

Parathyroid adenoma

Adrenal tumors

Adrenal cortical tumors

Adrenal cortical tumors

Tumors of the adrenal medulla and extra-adrenal paraganglia

Sympathetic paraganglioma

Parasympathetic paraganglioma (head and neck paraganglioma)

Pheochromocytoma

Composite pheochromocytoma/paraganglioma

Neuroendocrine neoplasms

Neuroendocrine tumors

Other neuroendcrine tumors

Conjunctival neoplasms

Hamartomas

Epibulbar choristoma

Epibulbar osseous choristoma

Phakomatous choristoma

Melanocytic neoplasms

Conjunctival junctional, compound, and subepithelial nevi

Inflamed juvenile conjunctival nevus

Uveal neoplasms

Diffuse choroidal neurofibroma and ganglioneuroma

Lisch nodule (iris hamartoma)

Retinal and neuroepithelial tumors

Retinocytoma

Retinoblastoma

Medulloepithelioma

Optic nerve tumors

Pilocytic astrocytoma and other gliomas of the optic nerve

Ovarian tumors

Sex cord stromal tumors

Ovarian fibroma

Sclerosing stromal tumor

Juvenile granulosa cell tumor of the ovary

Sex cord tumor with annular tubules

Papillary cystadenoma

Sertoli-Leydig cell tumor

Gynandroblastoma

Other ovarian tumors

Small cell carcinoma of the ovary, hypercalcemic type

Lower female genital tract tumors

Epithelial tumors

Mesonephric remnants and hyperplasia

Mullerian papilloma

Condyloma acuminatum

Peritoneal tumors

Mesothelial tumors

Peritoneal inclusion cysts

Syndromes predisposing primarily to neural tumors

Neurofibromatosis type 1

Neurofibromatosis type 2

Tuberous sclerosis

Nevoid basal cell carcinoma syndrome (Gorlin syndrome)

Retinoblastoma syndrome

Syndromes predisposing primarily to endocrine tumors

Von Hippel-Lindau syndrome

Hereditary pheochromocytoma-paraganglioma syndromes

Syndromes predisposing primarily to Wilms tumors

WAGR syndrome

Beckwith-Wiedemann and related overgrowth syndromes

Syndromes predisposing primarily to gastrointestinal tumors

Familial adenomatous polyposis

Lynch syndrome

Other syndromes

Xeroderma pigmentosum

Rothmund-Thomson syndrome

Li-Fraumeni syndrome

DICER1 syndrome

BAP1 tumor predisposition syndrome

Constitutional mismatch repair deficiency syndrome

Rhabdoid tumor predisposition syndrome

Non-invasive germ cell neoplasia

Intratublar germ cell neoplasia (male gonadal)

Gonadoblastoma

Germinoma-family tumors

Germinoma/dysgerminoma/seminoma

Non-ferminomatous germ cell tumors

Mature cystic teratoma

Extragonadal teratoma

Monodermal teratomas (female gonadal)

Immature teratoma (female gonadal)

Prepubertal-type testicular teratoma

Postpubertal-type teratoma

Embryonal carcinoma

Yolk sac tumor

Fetus in fetu

Choriocarcinoma (non-gestational)

Malignant mixed germ cell tumors

Benign tumors

Squamous papilloma and papillomatosis

White sponge nevus

Congential granular cell epulis

Central giant cell granuloma

Odontogenic tumors

Ossifying fibroma

Sinonasal tract myxoma

Nasal dermoid cyst

Nasopharyngeal dermoid

Nasal chondromesenchymal hamartoma

Pleomorphic adenoma

Malignant tumors

Mucoepidermoid carcinoma

Acinic cell carcinoma

Sialoblastoma

Nasopharyngeal carcinoma

NUT carcinoma

Melanotic neuroectodermal tumor of infancy

Myeloid neoplasms

Myeloproliferative neoplasms

Chronic myeloid leukemia (CML)

Juvenile myelomonocytic leukemia

Myelodysplastic syndromes

Refractory cytopenia of childhood (childhood myelodysplastic neoplasm with low blasts)

Myelodysplastic syndrome with excess blasts (childhood myelodysplastic neoplasm with increased blasts)

Acute myeloid leukemia

Acute myeloid leukemias defined by differentiation

Acute myeloid leukemias with defining genetic abnormalities.

Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions

Myeloid neoplasms associated with germline predisposition

Myeloid proliferations associated with Down syndrome

Mast cell neoplasia

Mastocytosis

Lymphoid neoplasms

Precursor lymphoid neoplasms

B-lymphoblastic leukemia/lymphoma

T and NK lymphoblastic leukemia/lymphoma

Mature B-cell neoplasms

Primary mediastinal large B cel lymphoma

Diffuse large B cell lymphoma NOS

EBV positive diffuse large B cel lymphoma

Large B cell lymphoma with IRF4 rearrangement

Pediatric type follicular lymphoma

Pediatric nodal marginal zone lymphoma

ALK-positive large B cell lymphoma

Lymphomatoid granulomatosis

Plasmablastic lymphoma

Mediastinal grey zone lymphoma

Burkitt lymphoma

High grade B cell lymphoma with 11q aberration

Mature T/NK cell neoplasms

Peripheral T cel lymphoma NOS

Aggressive NK-cell leukemia

Primary cutaneous T cell neoplasms

Mycosis fungoides

Primary cutaneous CD30 + T cell lymphoproliferative disorders

Subcutaneous panniculitis like T cel lymphoma

Anaplastic large cell lymphoma

ALK-positive anaplastic large cell lymphoma

Hepatosplenic T cell lymphoma

Hepatosplenic T cell lymphoma

EBV-positive lymphoproliferative diseases of childhood

Systemic EBV-positive T cell lymphoma of childhood

Hydroa vacciniforme lymphoprolifeartive disoder.

Hodgkin Lymphoma

Classic Hodgkin lymphoma

Nodular lymphocyte predominant Hodgkin lymphoma

Histiocytic and dendritic cell neoplasms

Langerhaans cell histiocytosis and related disorders

Immunodeficiency-associated lymphoproliferative disorders

Primary immunodeficiency-associated lymphoproliferative disorders

Posttransplant lymphoproliferative disorders

HIV associated lymphoproliferative disorders

Ganglioneuroma

Ganglioneuroblastoma, intermixed

Neuroblastoma

Ganglioneuroblastoma, nodular (and other composite neuroblastic tumors)

Renal tumors

Nephroblastic and related tumors

Pediatric cystic nephroma

Nephroblastoma

Molecularly defined renal tumors

Renal cell carcinoma with MiT translocations

ALK-rearranged renal cell carcinoma

Eosinophilic solid and cystic renal cell carcinoma

SMARCB1-deficient renal medullary carcinoma

Metanephric tumors

Metanephric adenoma

Metanephric adenofibroma

Metanephric stromal tumor

Mesenchymal renal tumors

Ossifying renal tumor of infancy

Mesoblastic nephroma

Clear cell sarcoma of the kidney

Malignant rhabdoid tumor of the kidney

Anaplastic sarcoma of the kidney

Renal Ewing sarcoma

Testicular tumors

Juvenile granulosa cell tumor of the testis

Hamartomas

Hamartomas

Epithelial neoplasms

Squamous neoplasms

Angiokeratoma

Epidermal nevi

Pilomatricoma

Melanocytic neoplasms

Nevi

Congenital nevi

Junctional, compound, and dermal nevi

Blue nevus

Spitz nevus

Pigmented spindle cell nevus (Reed nevus)

Melanoma

Melanoma

Soft tissue tumors

Adipocytic tumors

Lipomatosis

Lipoblastoma/lipoblastomatosis

Liposarcoma

Fibroblastic and myofibroblastic tumors

Fasciitis/myositis

Fibrodysplasia ossificans progressiva

Fibroma of tendon sheath

Gardner fibroma

Fibrous hamartoma of infancy

Lipofibromatosis

Inclusion body infantile digital fibromatosis

Juvenile hyaline fibromatosis (hyaline fibromatosis syndrome)

Fibromatosis colli

Calcifying aponeurotic fibroma

Sinonasal angiofibroma

Plantar/palmar fibromatoses

Dermatofibrosarcoma protuberans

Desmoid fibromatosis

EWSR1:SMAD3-rearranged fibroblastic tumor

Infantile fibrosarcoma

Pediatric NTRK-rearranged spindle cell neoplasm

Low-grade fibromyxoid sarcoma/sclerosing epithelioid fibrosarcoma

Inflammatory myofibroblastic tumor

Low-grade myofibroblastic sarcoma

So-called fibrohistiocytic tumors

Fibrous histiocytoma

Plexiform fibrohistiocytic tumor

Tenosynovial giant cell tumor

Vascular tumors

Capillary malformations

Venous malformations

Arteriovenous malformations

Intramuscular vascular anomalies

Lymphatic anomalies

Congenital hemangioma

Infantile hemangioma

Hemangioma of placenta

Lobular capillary hemangioma (pyogenic granuloma)

Epithelioid hemangioma

Tufted angioma and kaposiform hemangioendothelioma

Papillary intralymphatic angioendothelioma and retiform hemangioendothelioma

Pseudomyogenic hemangioendothelioma

Kaposi sarcoma

Epithelioid hemangioendothelioma

Angiosarcoma

Pericytic (perivascular) tumors

Myofibroma and myopericytoma

Glomus tumor and glomuvenous malformation

Smooth muscle tumors

EBV-associated smooth muscle tumor

Skeletal muscle tumors

Rhabdomyoma

Rhabdomyosarcomas

Ectomesenchymoma

Gastrointestinal stromal tumor

Pediatric gastrointestinal stromal tumor

Peripheral nerve sheath tumors

Schwannoma

Neurofibroma

Perineurioma

Hybrid nerve sheath tumor

Granular cell tumor

Solitary circumscribed neuroma

Ectopic meningioma and meningiothelial hamartoma

Benign triton tumor/neuromuscular choristoma

Malignant peripheral nerve sheath tumor

Tumors of uncertain derivation

Intramuscular/juxta-articular-myxoma

Superficial angiomyxoma

Deep angiomyxoma

Angiomatoid fibrous histiocytoma

Clear cell sarcoma of soft tissue

Alveolar soft part sarcoma

Extrarenal rhabdoid tumor

PEComa

Synovial sarcoma

Epithelioid sarcoma

Myoepithelial tumors of soft tissue

Phosphaturic mesenchymal tumor

Desmoplastic small round cell tumor

Undifferentiated sarcomas

Undifferentiated small round cell sarcomas of soft tissue and bone

Ewing sarcoma

Round cell sarcoma with EWSR::non-ETS fusions

CIC-rearranged sarcoma

Sarcoma with BCOR genetic alterations

Bone tumors

Osteogenic tumors

Subungual exostosis

Bizarre parosteal osteochondromatous proliferation

Osteoblastoma

Osteoid osteoma

Chondromesenchymal hamartoma of the chest wall

Osteosarcoma

Chondrogenic tumors

Chondroblastoma

Osteochondroma

Chondromyxoid fibroma

Enchondroma and enchondromatosis

Chondrosarcoma

Mesenchymal chondrosarcoma

Other bone tumors

Vascular tumors of bone

Aneurysmal bone cyst

Giant cell tumor of bone

Non-ossifying fibroma

Notochordal tumors

Simple bone cyst

Adamantinoma

Osteofibrous dysplasia

Fibrous dysplasia

Lung tumors

Fetal lung interstitial tumor

Congenital peribronchial myofibroblastic tumor

Pleuropulmonary blastoma

Heart tumors 

Cardiac rhabdomyoma